Redox-Neutral Imination of Alcohol with Azide: A Sustainable Alternative to the Staudinger/Aza-Wittig Reaction
نویسندگان
چکیده
The traditional Staudinger/aza-Wittig reaction represents one of the most powerful tools for imine formation. However, this multistep procedure, sacrificial phosphine has to be used, resulting in difficulties purification process and waste disposal at same time. Here, we report a redox-neutral azide–alcohol imination methodology enabled by base-metal nickel PN3 pincer catalyst. one-step, waste-free, high atom-economical features highlight its advantages further. Moreover, mechanistic insight suggests non-metal–ligand cooperation pathway based on observation an intermediate density functional theory calculations.
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ژورنال
عنوان ژورنال: ACS Catalysis
سال: 2021
ISSN: ['2155-5435']
DOI: https://doi.org/10.1021/acscatal.1c00379